C4 Rabbit pAb
Cat No.: APA4713
Size：
| Product Name: | C4 Rabbit pAb |
| Cat No.: | APA4713 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,ICC/IF,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:2000 ICC/IF: 1:20-1:50 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human C4 |
| calculated molecular weight: | 193 kDa |
| observed molecular weight: | 193 kDa |
| genbank accession number: | P0C0L4 |
| gene id (ncbi): | 720 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |