Werner--s syndrome helicase WRN Rabbit pAb
Cat No.: APA4531
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| Product Name: | Werner--s syndrome helicase WRN Rabbit pAb |
| Cat No.: | APA4531 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Werner--s syndrome helicase WRN |
| calculated molecular weight: | 163 kDa |
| observed molecular weight: | 200 kDa |
| genbank accession number: | Q14191 |
| gene id (ncbi): | 7486 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | RECQ3; RECQL2; RECQL3 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3-- to 5-- exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017] |