Bag3 Rabbit pAb
Cat No.: APA4520
Size：
| Product Name: | Bag3 Rabbit pAb |
| Cat No.: | APA4520 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 IHC: 1:20 IP: 1:20-1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Bag3 |
| calculated molecular weight: | 62 kDa |
| observed molecular weight: | 74-80 kDa |
| genbank accession number: | O95817 |
| gene id (ncbi): | 9531 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | BIS; MFM6; BAG-3; CAIR-1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |