TPA Tissue Plasminogen Activator Rabbit pAb
Cat No.: APA4470
Size：
| Product Name: | TPA Tissue Plasminogen Activator Rabbit pAb |
| Cat No.: | APA4470 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IHC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:2000 IHC: 1:20-1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human TPA Tissue Plasminogen Activator |
| calculated molecular weight: | 63 kDa |
| observed molecular weight: | 63 kDa |
| genbank accession number: | P00750 |
| gene id (ncbi): | 5327 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | TPA; T-PA |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |