Interferon regulatory factor 9 Rabbit pAb
Cat No.: APA4322
Size：
| Product Name: | Interferon regulatory factor 9 Rabbit pAb |
| Cat No.: | APA4322 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,ICC/IF,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000-1:10000 ICC/IF: 1:20-1:50 FC: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Interferon regulatory factor 9 |
| calculated molecular weight: | 44 kDa |
| observed molecular weight: | 44 kDa |
| genbank accession number: | Q00978 |
| gene id (ncbi): | 10379 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | p48; IRF-9; ISGF3; ISGF3G |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |