IREB2 Rabbit pAb
Cat No.: APA4191
Size：
| Product Name: | IREB2 Rabbit pAb |
| Cat No.: | APA4191 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 FC: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human IREB2 |
| calculated molecular weight: | 105 kDa |
| observed molecular weight: | 105 kDa |
| genbank accession number: | P48200 |
| gene id (ncbi): | 3658 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ACO3; IRP2; IRP2AD; IRE-BP2; IRE-BP 2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5-- or 3-- UTRs. Binding to the 5-- UTR represses translation, while binding to the 3-- UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |