BRCA1 Rabbit pAb
Cat No.: APA4187
Size：
| Product Name: | BRCA1 Rabbit pAb |
| Cat No.: | APA4187 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | IHC,ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | IHC: 1:50 ICC/IF: 1:200 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human BRCA1 |
| calculated molecular weight: | 208 kDa |
| observed molecular weight: | |
| genbank accession number: | P38398 |
| gene id (ncbi): | 672 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] |