PDK4 Rabbit pAb
Cat No.: APA4108
Size：
| Product Name: | PDK4 Rabbit pAb |
| Cat No.: | APA4108 |
| source: | Rabbit |
| reactivity: | Mouse, Rat |
| applications: | WB,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 FC: 1:20 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of mouse PDK4 |
| calculated molecular weight: | 47 kDa |
| observed molecular weight: | 47 kDa |
| genbank accession number: | O70571 |
| gene id (ncbi): | 27273 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | AV005916 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. |