CD163 Rabbit pAb
Cat No.: APA4096
Size:
Product Name: | CD163 Rabbit pAb |
Cat No.: | APA4096 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB,IHC |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 IHC: 1:50 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of mouse CD163 |
calculated molecular weight: | 126 kDa |
observed molecular weight: | 150 kDa |
genbank accession number: | Q2VLH6 |
gene id (ncbi): | 93671 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | CD163v2; CD163v3 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). |