CD31 Rabbit pAb
Cat No.: APA3956
Size：
| Product Name: | CD31 Rabbit pAb |
| Cat No.: | APA3956 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | IHC |
| clonality: | Polyclonal |
| recommended dilution: | IHC: 1:20-1:500 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of mouse CD31 |
| calculated molecular weight: | 83 kDa |
| observed molecular weight: | |
| genbank accession number: | Q08481 |
| gene id (ncbi): | 18613 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | Cd31; Pecam; C85791; PECAM-1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting --detachment-- signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell--s active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. |