JAML Rabbit pAb
Cat No.: APA3764
Size：
| Product Name: | JAML Rabbit pAb |
| Cat No.: | APA3764 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:2000 FC: 1:20 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human JAML |
| calculated molecular weight: | 44 kDa |
| observed molecular weight: | 60 kDa |
| genbank accession number: | Q86YT9 |
| gene id (ncbi): | 120425 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | AMICA; Gm638; AMICA1; CREA7-1; CREA7-4 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |