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KCTD21 Rabbit pAb

Cat No.: APA3671
Size:
Product Name: KCTD21 Rabbit pAb
Cat No.: APA3671
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000
FC: 1:50
format: Liquid
isotype: IgG
immunogen: Recombinant protein of human KCTD21
calculated molecular weight: 30 kDa
observed molecular weight: 30 kDa
genbank accession number: Q4G0X4
gene id (ncbi): 283219
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: KCASH2
category: Primary Ab
concentration: 0.5mg/ml
background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).