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BCRP/ABCG2 Rabbit pAb

Cat No.: APA3667
Size:
Product Name: BCRP/ABCG2 Rabbit pAb
Cat No.: APA3667
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:500
FC: 1:20
format: Liquid
isotype: IgG
immunogen: Recombinant protein of human BCRP/ABCG2
calculated molecular weight: 72 kDa
observed molecular weight: 72 kDa
genbank accession number: Q9UNQ0
gene id (ncbi): 9429
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
category: Primary Ab
concentration: 0.5mg/ml
background: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]