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CD41 Rabbit pAb

Cat No.: APA3659
Size:
Product Name: CD41 Rabbit pAb
Cat No.: APA3659
source: Rabbit
reactivity: Mouse, Rat
applications: WB,IHC
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:100
format: Liquid
isotype: IgG
immunogen: Recombinant protein of mouse CD41
calculated molecular weight: 113 kDa
observed molecular weight: 113 kDa
genbank accession number: Q9QUM0
gene id (ncbi): 16399
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: CD41; CD41B; GpIIb; AI172977; alphaIIb
category: Primary Ab
concentration: 0.5mg/ml
background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.