Granulin Rabbit pAb
Cat No.: APA3655
Size：
| Product Name: | Granulin Rabbit pAb |
| Cat No.: | APA3655 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,ICC/IF,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 ICC/IF: 1:20 FC: 1:50 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Granulin |
| calculated molecular weight: | 64 kDa |
| observed molecular weight: | 55,88 kDa |
| genbank accession number: | P28799 |
| gene id (ncbi): | 2896 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | GEP; GP88; PEPI; PGRN; CLN11; PCDGF |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] |