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FBXL11 Rabbit pAb

Cat No.: APA3627
Size:
Product Name: FBXL11 Rabbit pAb
Cat No.: APA3627
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC,ICC/IF,IP
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:50
ICC/IF: 1:200
IP: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human FBXL11
calculated molecular weight: 133 kDa
observed molecular weight: 133 kDa
genbank accession number: Q9Y2K7
gene id (ncbi): 22992
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]