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alpha A Crystallin Rabbit pAb

Cat No.: APA3576
Size:
Product Name: alpha A Crystallin Rabbit pAb
Cat No.: APA3576
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,ICC/IF
clonality: Polyclonal
recommended dilution: WB: 1:1000
ICC/IF: 1:100
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human alpha A Crystallin
calculated molecular weight: 20 kDa
observed molecular weight: 20 kDa
genbank accession number: P02489
gene id (ncbi): 1409
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: CRYA1; HSPB4; CTRCT9
category: Primary Ab
concentration: 0.5mg/ml
background: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]