ALKBH5 Rabbit pAb
Cat No.: APA3465
Size:
Product Name: | ALKBH5 Rabbit pAb |
Cat No.: | APA3465 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB,IHC,FC |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 IHC: 1:500 FC: 1:20 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human ALKBH5 |
calculated molecular weight: | 44 kDa |
observed molecular weight: | 44 kDa |
genbank accession number: | Q6P6C2 |
gene id (ncbi): | 54890 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | ABH5; OFOXD; OFOXD1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N6-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity). |