• Drop us a line for any questions: info@assayvector.com

Cellular Apoptosis Susceptibility Rabbit pAb

Cat No.: APA3457
Size:
Product Name: Cellular Apoptosis Susceptibility Rabbit pAb
Cat No.: APA3457
source: Rabbit
reactivity: Human, Mouse
applications: WB,IHC,ICC/IF,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000-1:5000
IHC: 1:50
ICC/IF: 1:100
FC: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human Cellular Apoptosis Susceptibility
calculated molecular weight: 110 kDa
observed molecular weight: 110 kDa
genbank accession number: P55060
gene id (ncbi): 1434
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: CAS; CSE1; XPO2
category: Primary Ab
concentration: 0.5mg/ml
background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]