IL12B Rabbit pAb
Cat No.: APA3403
Size：
| Product Name: | IL12B Rabbit pAb |
| Cat No.: | APA3403 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,ICC/IF,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000-1:5000 ICC/IF: 1:20 FC: 1:500 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human IL12B |
| calculated molecular weight: | 37 kDa |
| observed molecular weight: | 40 kDa |
| genbank accession number: | P29460 |
| gene id (ncbi): | 3593 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |