RIP Rabbit pAb
Cat No.: APA3341
Size：
| Product Name: | RIP Rabbit pAb |
| Cat No.: | APA3341 |
| source: | Rabbit |
| reactivity: | Mouse |
| applications: | WB,IHC,ICC/IF,FC,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:100 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of mouse RIP |
| calculated molecular weight: | 75 kDa |
| observed molecular weight: | 75 kDa |
| genbank accession number: | Q60855 |
| gene id (ncbi): | 19766 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | RIP; Rinp; Rip1; D330015H01Rik |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at --Ser-728-- in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via --Lys-63---link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. |