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MDA5 Rabbit pAb

Cat No.: APA3328
Size:
Product Name: MDA5 Rabbit pAb
Cat No.: APA3328
source: Rabbit
reactivity: Human
applications: WB,IHC,ICC/IF
clonality: Polyclonal
recommended dilution: WB: 1:1000-1:5000
IHC: 1:50
ICC/IF: 1:100
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human MDA5
calculated molecular weight: 117 kDa
observed molecular weight: 117 kDa
genbank accession number: Q9BYX4
gene id (ncbi): 64135
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: AGS7; Hlcd; MDA5; MDA-5; RLR-2; IDDM19; SGMRT1
category: Primary Ab
concentration: 0.5mg/ml
background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]