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Factor X Rabbit pAb

Cat No.: APA3249
Size:
Product Name: Factor X Rabbit pAb
Cat No.: APA3249
source: Rabbit
reactivity: Human
applications: WB
clonality: Polyclonal
recommended dilution: WB: 1:5000
format: Liquid
isotype: IgG
immunogen: Recombinant protein of human Factor X
calculated molecular weight: 55 kDa
observed molecular weight: 60 kDa
genbank accession number: P00742
gene id (ncbi): 2159
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: FX; FXA
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]