KRIT1 Rabbit pAb
Cat No.: APA3236
Size:
Product Name: | KRIT1 Rabbit pAb |
Cat No.: | APA3236 |
source: | Rabbit |
reactivity: | Human, Mouse |
applications: | WB,IHC,ICC/IF |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human KRIT1 |
calculated molecular weight: | 84 kDa |
observed molecular weight: | 84 kDa |
genbank accession number: | O00522 |
gene id (ncbi): | 889 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | CAM; CCM1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] |