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Syntrophin alpha 1 Rabbit pAb

Cat No.: APA3234
Size:
Product Name: Syntrophin alpha 1 Rabbit pAb
Cat No.: APA3234
source: Rabbit
reactivity: Human, Mouse
applications: WB,IHC,ICC/IF,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000-1:5000
IHC: 1:50
ICC/IF: 1:50
FC: 1:50
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human Syntrophin alpha 1
calculated molecular weight: 54 kDa
observed molecular weight: 54 kDa
genbank accession number: Q13424
gene id (ncbi): 6640
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: SNT1; LQT12; TACIP1; dJ1187J4.5
category: Primary Ab
concentration: 0.5mg/ml
background: Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]