Cullin 5 Rabbit pAb
Cat No.: APA3228
Size:
Product Name: | Cullin 5 Rabbit pAb |
Cat No.: | APA3228 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000-1:5000 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human Cullin 5 |
calculated molecular weight: | 91 kDa |
observed molecular weight: | 91 kDa |
genbank accession number: | Q93034 |
gene id (ncbi): | 8065 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | CUL-5; VACM1; VACM-1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |