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SHC Rabbit pAb

Cat No.: APA3227
Size:
Product Name: SHC Rabbit pAb
Cat No.: APA3227
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC,ICC/IF,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:50
ICC/IF: 1:50
FC: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human SHC
calculated molecular weight: 63 kDa
observed molecular weight: 46,52,66 kDa
genbank accession number: P29353
gene id (ncbi): 6464
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: SHC; SHCA
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]