ULK1 Rabbit pAb
Cat No.: APA3223
Size：
| Product Name: | ULK1 Rabbit pAb |
| Cat No.: | APA3223 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000-1:10000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human ULK1 |
| calculated molecular weight: | 113 kDa |
| observed molecular weight: | 130 kDa |
| genbank accession number: | O75385 |
| gene id (ncbi): | 8408 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | ATG1; ATG1A; UNC51; hATG1; Unc51.1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). |