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CEACAM1 Rabbit pAb

Cat No.: APA3221
Size:
Product Name: CEACAM1 Rabbit pAb
Cat No.: APA3221
source: Rabbit
reactivity: Human
applications: WB,ICC/IF,IP
clonality: Polyclonal
recommended dilution: WB: 1:2000-1:10000
ICC/IF: 1:20
IP: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human CEACAM1
calculated molecular weight: 58 kDa
observed molecular weight: 58 kDa
genbank accession number: P13688
gene id (ncbi): 634
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: BGP; BGP1; BGPI
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]