GSDMA Rabbit pAb
Cat No.: APA3206
Size:
Product Name: | GSDMA Rabbit pAb |
Cat No.: | APA3206 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human GSDMA |
calculated molecular weight: | 49 kDa |
observed molecular weight: | 49 kDa |
genbank accession number: | Q96QA5 |
gene id (ncbi): | 284110 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | GSDM; FKSG9; GSDM1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). |