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IL1 Receptor I Rabbit pAb

Cat No.: APA3201
Size:
Product Name: IL1 Receptor I Rabbit pAb
Cat No.: APA3201
source: Rabbit
reactivity: Mouse
applications: WB
clonality: Polyclonal
recommended dilution: WB: 1:1000
format: Liquid
isotype: IgG
immunogen: Recombinant protein of mouse IL1 Receptor I
calculated molecular weight: 67 kDa
observed molecular weight: 67,80 kDa
genbank accession number: P13504
gene id (ncbi): 16177
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: IL-iR; CD121a; CD121b; IL-1R1; Il1r-1
category: Primary Ab
concentration: 0.5mg/ml
background: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).