SET7 Rabbit pAb
Cat No.: APA3180
Size：
| Product Name: | SET7 Rabbit pAb |
| Cat No.: | APA3180 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human SET7 |
| calculated molecular weight: | 41 kDa |
| observed molecular weight: | 41 kDa |
| genbank accession number: | Q8WTS6 |
| gene id (ncbi): | 80854 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | KMT7; SET7; SET9; SET7/9 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Histone methyltransferase that specifically monomethylates --Lys-4-- of histone H3. H3 --Lys-4-- methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates --Lys-189-- of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates --Lys-372-- of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |