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Rasgrp1 Rabbit pAb

Cat No.: APA3169
Size:
Product Name: Rasgrp1 Rabbit pAb
Cat No.: APA3169
source: Rabbit
reactivity: Human, Mouse
applications: WB
clonality: Polyclonal
recommended dilution: WB: 1:1000
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human Rasgrp1
calculated molecular weight: 90 kDa
observed molecular weight: 90 kDa
genbank accession number: O95267
gene id (ncbi): 10125
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII
category: Primary Ab
concentration: 0.5mg/ml
background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]