Rasgrp1 Rabbit pAb
Cat No.: APA3169
Size：
| Product Name: | Rasgrp1 Rabbit pAb |
| Cat No.: | APA3169 |
| source: | Rabbit |
| reactivity: | Human, Mouse |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Rasgrp1 |
| calculated molecular weight: | 90 kDa |
| observed molecular weight: | 90 kDa |
| genbank accession number: | O95267 |
| gene id (ncbi): | 10125 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] |