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UMOD Rabbit pAb

Cat No.: APA3153
Size:
Product Name: UMOD Rabbit pAb
Cat No.: APA3153
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC,IP
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:200
IP: 1:20
format: Liquid
isotype: IgG
immunogen: Recombinant protein of human UMOD
calculated molecular weight: 70 kDa
observed molecular weight: 115 kDa
genbank accession number: P07911
gene id (ncbi): 7369
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2
category: Primary Ab
concentration: 0.5mg/ml
background: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]