Indoleamine 2,3-dioxygenase Rabbit pAb
Cat No.: APA3067
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| Product Name: | Indoleamine 2,3-dioxygenase Rabbit pAb |
| Cat No.: | APA3067 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000 ICC/IF: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Indoleamine 2,3-dioxygenase |
| calculated molecular weight: | 45 kDa |
| observed molecular weight: | 45 kDa |
| genbank accession number: | P14902 |
| gene id (ncbi): | 3620 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | IDO; INDO; IDO-1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |