Indoleamine 2,3-dioxygenase Rabbit pAb
Cat No.: APA3067
Size:
Product Name: | Indoleamine 2,3-dioxygenase Rabbit pAb |
Cat No.: | APA3067 |
source: | Rabbit |
reactivity: | Human |
applications: | WB,ICC/IF |
clonality: | Polyclonal |
recommended dilution: | WB: 1:2000 ICC/IF: 1:20 |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human Indoleamine 2,3-dioxygenase |
calculated molecular weight: | 45 kDa |
observed molecular weight: | 45 kDa |
genbank accession number: | P14902 |
gene id (ncbi): | 3620 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | IDO; INDO; IDO-1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |