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Bcl10 Rabbit pAb

Cat No.: APA3057
Size:
Product Name: Bcl10 Rabbit pAb
Cat No.: APA3057
source: Rabbit
reactivity: Human
applications: WB,IHC,ICC/IF,FC,IP
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:20
ICC/IF: 1:50
FC: 1:50
IP: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human Bcl10
calculated molecular weight: 26 kDa
observed molecular weight: 26 kDa
genbank accession number: O95999
gene id (ncbi): 8915
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
category: Primary Ab
concentration: 0.5mg/ml
background: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]