NOLC1 Rabbit pAb
Cat No.: APA3030
Size:
Product Name: | NOLC1 Rabbit pAb |
Cat No.: | APA3030 |
source: | Rabbit |
reactivity: | Human, Mouse |
applications: | WB,IHC,ICC/IF,FC |
clonality: | Polyclonal |
recommended dilution: | WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:100 FC: 1:50 |
format: | Liquid |
isotype: | IgG |
immunogen: | A synthetic peptide of human NOLC1 |
calculated molecular weight: | 74 kDa |
observed molecular weight: | 110 kDa |
genbank accession number: | Q14978 |
gene id (ncbi): | 9221 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | P130; NOPP130; NOPP140; NS5ATP13 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). |