Mre11 Rabbit pAb
Cat No.: APA2915
Size:
Product Name: | Mre11 Rabbit pAb |
Cat No.: | APA2915 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB,IHC,FC |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 IHC: 1:200 FC: 1:100 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human Mre11 |
calculated molecular weight: | 81 kDa |
observed molecular weight: | 81 kDa |
genbank accession number: | P49959 |
gene id (ncbi): | 4361 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | ATLD; HNGS1; MRE11A; MRE11B |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3-- to 5-- exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3-- to 5-- exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |