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TRIM56 Rabbit pAb

Cat No.: APA2909
Size:
Product Name: TRIM56 Rabbit pAb
Cat No.: APA2909
source: Rabbit
reactivity: Human
applications: WB,IHC,ICC/IF,FC
clonality: Polyclonal
recommended dilution: WB: 1:2000-1:10000
IHC: 1:20
ICC/IF: 1:50
FC: 1:20-1:100
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human TRIM56
calculated molecular weight: 82 kDa
observed molecular weight: 82 kDa
genbank accession number: Q9BRZ2
gene id (ncbi): 81844
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: RNF109
category: Primary Ab
concentration: 0.5mg/ml
background: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to --Lys-63---linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).