TRIM56 Rabbit pAb
Cat No.: APA2909
Size：
| Product Name: | TRIM56 Rabbit pAb |
| Cat No.: | APA2909 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20-1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human TRIM56 |
| calculated molecular weight: | 82 kDa |
| observed molecular weight: | 82 kDa |
| genbank accession number: | Q9BRZ2 |
| gene id (ncbi): | 81844 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | RNF109 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to --Lys-63---linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). |