Bag3 Rabbit pAb
Cat No.: APA2908
Size:
Product Name: | Bag3 Rabbit pAb |
Cat No.: | APA2908 |
source: | Rabbit |
reactivity: | Human, Mouse, Rat |
applications: | WB,FC |
clonality: | Polyclonal |
recommended dilution: | WB: 1:1000 FC: 1:20 |
format: | Liquid |
isotype: | IgG |
immunogen: | Recombinant protein of human Bag3 |
calculated molecular weight: | 62 kDa |
observed molecular weight: | 80 kDa |
genbank accession number: | O95817 |
gene id (ncbi): | 9531 |
purification method: | Affinity Purification |
conjugate: | Un-conjugated |
storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
synonyms: | BIS; MFM6; BAG-3; CAIR-1 |
category: | Primary Ab |
concentration: | 0.5mg/ml |
background: | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] |