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DUSP9 Rabbit pAb

Cat No.: APA2867
Size:
Product Name: DUSP9 Rabbit pAb
Cat No.: APA2867
source: Rabbit
reactivity: Human
applications: WB,ICC/IF
clonality: Polyclonal
recommended dilution: WB: 1:1000
ICC/IF: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human DUSP9
calculated molecular weight: 42 kDa
observed molecular weight: 42 kDa
genbank accession number: Q99956
gene id (ncbi): 1852
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: MKP4; MKP-4
category: Primary Ab
concentration: 0.5mg/ml
background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]