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DAP12 Rabbit pAb

Cat No.: APA2848
Size:
Product Name: DAP12 Rabbit pAb
Cat No.: APA2848
source: Rabbit
reactivity: Human
applications: WB,ICC/IF,FC
clonality: Polyclonal
recommended dilution: WB: 1:1000
ICC/IF: 1:50
FC: 1:20
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human DAP12
calculated molecular weight: 12 kDa
observed molecular weight: 12 kDa
genbank accession number: O43914
gene id (ncbi): 7305
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: DAP12; KARAP; PLOSL
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]