Angiotensin Converting Enzyme 1 Rabbit pAb
Cat No.: APA2038
Size：
| Product Name: | Angiotensin Converting Enzyme 1 Rabbit pAb |
| Cat No.: | APA2038 |
| source: | Rabbit |
| reactivity: | Human, Mouse |
| applications: | WB,IHC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human Angiotensin Converting Enzyme 1 |
| calculated molecular weight: | 150 kDa |
| observed molecular weight: | 180 kDa |
| genbank accession number: | P12821 |
| gene id (ncbi): | 1636 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | DCP; ACE1; DCP1; CD143 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes an enzyme involved in in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. ACE also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored proteins in testes. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer--s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2020] |