GIRK1 Rabbit pAb
Cat No.: APA2027
Size：
| Product Name: | GIRK1 Rabbit pAb |
| Cat No.: | APA2027 |
| source: | Rabbit |
| reactivity: | Human, Mouse, Rat |
| applications: | WB,FC |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 FC: 1:20-1:100 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human GIRK1 |
| calculated molecular weight: | 57 kDa |
| observed molecular weight: | 57 kDa |
| genbank accession number: | P48549 |
| gene id (ncbi): | 3760 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | KGA; GIRK1; KIR3.1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down--s syndrome, ataxia, and Parkinson--s disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012] |