PML Protein Rabbit pAb
Cat No.: APA2015
Size：
| Product Name: | PML Protein Rabbit pAb |
| Cat No.: | APA2015 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF,IP |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:200 ICC/IF: 1:100 IP: 1:20 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human PML Protein |
| calculated molecular weight: | 98 kDa |
| observed molecular weight: | 98,117 kDa |
| genbank accession number: | P29590 |
| gene id (ncbi): | 5371 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | MYL; RNF71; PP8675; TRIM19 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein--s central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |