CD35 Rabbit pAb
Cat No.: APA1975
Size：
| Product Name: | CD35 Rabbit pAb |
| Cat No.: | APA1975 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB,IHC,ICC/IF |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human CD35 |
| calculated molecular weight: | 224 kDa |
| observed molecular weight: | 280 kDa |
| genbank accession number: | P17927 |
| gene id (ncbi): | 1378 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | KN; C3BR; C4BR; CD35 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene is a member of the receptors of complement activation (RCA) family and is located in the --cluster RCA-- region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer--s disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] |