MAP3K8/COT Rabbit pAb
Cat No.: APA1864
Size：
| Product Name: | MAP3K8/COT Rabbit pAb |
| Cat No.: | APA1864 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human MAP3K8/COT |
| calculated molecular weight: | 53 kDa |
| observed molecular weight: | 53 kDa |
| genbank accession number: | P41279 |
| gene id (ncbi): | 1326 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |