IL-1 beta Rabbit pAb
Cat No.: APA1731
Size：
| Product Name: | IL-1 beta Rabbit pAb |
| Cat No.: | APA1731 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:2000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human IL-1 beta |
| calculated molecular weight: | 31 kDa |
| observed molecular weight: | 17,31 kDa |
| genbank accession number: | P01584 |
| gene id (ncbi): | 3553 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | IL-1; IL1F2; IL1beta; IL1-BETA |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Patients with severe COVID-19 (Coronavirus Disease 2019) symptoms present elevated levels of pro-inflammatory cytokines such as IL-1B. SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2)-infected cells can produce elevated levels of IL-1B which strongly contributes to the immuno-mediated damage to the lungs as well as to other organs. [provided by RefSeq, Jun 2020] |