p27 KIP 1 Rabbit pAb
Cat No.: APA1657
Size：
| Product Name: | p27 KIP 1 Rabbit pAb |
| Cat No.: | APA1657 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | Recombinant protein of human p27 KIP 1 |
| calculated molecular weight: | 22 kDa |
| observed molecular weight: | 27 kDa |
| genbank accession number: | P46527 |
| gene id (ncbi): | 1027 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | KIP1; MEN4; CDKN4; MEN1B; P27KIP1 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] |