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Neuroserpin Rabbit pAb

Cat No.: APA1643
Size:
Product Name: Neuroserpin Rabbit pAb
Cat No.: APA1643
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB,IHC
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:50
format: Liquid
isotype: IgG
immunogen: Recombinant protein of human Neuroserpin
calculated molecular weight: 46 kDa
observed molecular weight: 46 kDa
genbank accession number: Q99574
gene id (ncbi): 5274
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: PI12; neuroserpin
category: Primary Ab
concentration: 0.5mg/ml
background: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]